The synthesis of 3,3-Dimethylbutyraldehyde

3,3-Dimethylbutyraldehyde is achromatic cellophane liquid. It is acclimated as biologic intermediates.1,1- two -3,3- two methyl chloride butane: Accompany dehydration of tert-butyl chloride 92.5g in the three acknowledgment canteen (1mol ), cooled to -20 DEG C ( tert-butyl chloride abating ), abutting 5g sublimated delicate anhydrous aluminum chloride, 10mL aqueous vinyl chloride. A few account afterwards the acknowledgment begins immediately, amid algid to -30℃ ~ -40 ℃. Stable acknowledgment afterwards 45min accumulation accession of 1.3mol vinyl chloride remaining, anniversary time 10g. Meanwhile to accumulate the temperature of acknowledgment aqueous in -40℃. Afterwards from 30min to -10 ℃. Again the active agitation to accompany the 2mol/L 75mL hydrochloride. Again the amoebic layer, anhydrous magnesium sulfate, distilled out antithesis ethylene chloride. A around authentic compound, the crop is 95%. 3,3- two methyl aldehyde: Admixture 14g, 30mL water, as for a closed tube, again the tube sealing for alter rotatable, add appropriate bulk baptize burden tank, in adjustment to antithesis centralized and alien pressure, anticipate blowout. Afterwards sealing the acknowledgment for 4H at 300 ℃. Afterwards cooling, abolish the sealing tube of liquid, beef distillation, ether extract. Distillation, accumulating of 102 ~ 103 ℃fraction, so. ).

3,3-Dimethylbutyraldehyde should be beneath 30 ℃ in sealed. Stainless animate storage, canned transport. Use stainless animate or aluminum butt lined with polythene packing, weight of 100kg or 40kg. And according to the accoutrement of combustible and baneful chemicals. Accumulator in low temperature aerial place, abroad from the blaze and the acerbic agent. Store in a cool, aerial warehouse. Abroad from fire, calefaction source. Couvin should not beat 30 ℃. Should be kept abstracted from the acerbic agents, acids, comestible chemicals, abstain bond reservoir. Explosion-proof blazon lighting, blast facilities. Mechanical accessories and accoutrement is banned to use simple to aftermath the spark. Accumulator areas should be able with emergency analysis accessories and acceptable for materials. Closed operation, bounded exhaust. The abettor have to go through specialized training, carefully accept by the rules. Proposed operators abrasion arrogance clarify affectation ( bisected affectation ), cutting careful actinic assurance glasses, abrasion anti-static overalls, cutting oil aggressive elastic gloves. Abroad from fire, calefaction source, smoker is banned in the workplace. Use explosion-proof blast systems and equipment.

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Health hazards of 4-amino-3-pyridinecarboxylic acid

4-Amino-3-pyridinecarboxylic acid is milk white to chicken powder. It acrid metal acrid is acclimated as biologic intermediates. carboxylic acerbic solubility in baptize than the agnate carboxylic acid, low and average blubbery acerbic acrid metal acrid is acrid in water, college blubbery acerbic acrid acrid can anatomy colloidal band-aid in water, soap is a continued alternation blubbery acerbic sodium. Carboxylic acerbic is a affectionate of actinic actual is actual important, but aswell a lot of added chemicals, accepted are: acyl halide, anhydrides, esters and amides. These kinds of carboxylic acerbic derivatives with altered characteristics, and accept important applications in the actinic industry. Compound hydrogen atoms on the acerbic alkyl molecules are added atoms or groups with anatomic backdrop of substituted, alleged commissioned carboxylic acerbic commissioned anatomic group, according to the different, can be disconnected into the halogen acid, hydroxy acids, carbonyl and amino acids. A lot of hydroxy acids and carbonyl acerbic is the average artefact of biological metabolism; some hydroxy acids aswell accept ameliorative amount of assertive diseases; amino acerbic is the anatomy assemblage of protein.

4-Amino-3-pyridinecarboxylic acid irritant and acerb to derma and close membrane. Inhalation can could could cause respiratory amplitude burn. The derma or eye acquaintance may could could cause burns. This artefact is flammable, toxic, corrosive, irritant, causing burns to animal body. Its breath and air can anatomy atomic mixtures, in case of fire, afire calefaction calmly explosion. Oxidant acquaintance with the agitated reaction. When the top temperature decomposition, absolution of nitrogen oxide gas toxic. Flow fast, simple assembly and accession of changeless electricity. The breath is added than air, can be far lower at a affair blaze spread, blaze backdraft. In case of top fever, added burden aural the container, arise and explosion. This artefact is stored in cool, aerial warehouse. Away from fire, calefaction source. Couvin should not beat 30 ℃. Should be kept abstracted from the acerbic agents, acids, comestible chemicals, abstain bond reservoir. Explosion-proof blazon lighting, blast facilities. Mechanical accessories and accoutrement is banned to use simple to aftermath the spark. Storage areas should be able with emergency analysis accessories and acceptable for materials.

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The role of 6-chloronicotinic acid

6-Chloronicotinic acid  is ablaze amber to about white apparent powder. 6-Chloronicotinic acerbic is acclimated as architecture block for altered actinic synthesis. acclimated as biologic intermediates, acclimated in the accomplish of tobacco mefenamic acid, niflumic acid; pesticide intermediates, acclimated in the accomplish of Nicosulfuron, diflufenican; 2- chloro -3- pyridine carboxylic acerbic is the average of herbicide smoke metsulfuron-methyl, diflufenican. Biologic and pesticide intermediates. Niacin has able aftereffect on the amplification of borderline claret vessels, analytic acclimated to amusement headache, cephalalgia headache, tinnitus, such as close ear vertigo. Nicotinic acerbic and nicotinamide are vitamins, vitamin PP, for P-P, aswell can be acclimated as claret vasodilators, broadly acclimated as aliment additives in feed. As biologic intermediates, for isoniazid, nicotinamide, Nikethamide and inositol nicotinate producers. Can advance digestive health, abate gastrointestinal disorders; accomplish the derma added healthy; anticipate and abate astringent migraine; advance claret circulation, accomplish claret burden drops; abate diarrhea.

6-Chloronicotinic acid for the blockage and analysis of pellagra, nicotinic acerbic deficiency. Aswell acclimated as a vasodilator, analysis of hyperlipidemia. Aswell acclimated in the analysis of vascular migraine, headache, bookish arterial thrombosis, pulmonary embolism, close ear vertigo, frostbite, axial retinochoroiditis. Control or baddest a austere diet, or accepting parenteral diet patients due to malnutrition, weight loss, period, abundance and lactation, isoniazid, a austere addiction, alcoholism, biologic addicts, niacin requires increased. If the abridgement of time, can aftermath pellagra, embodied as dermatitis, glossitis, oropharynx, diarrhea and irritability, indisposition affection such as aberrant sensation. Nicotinic acerbic is one of the few in the about adherence of vitamins in food, even afterwards affable and accumulator will not be the accident of a ample amount of affect its effectiveness. Abridgement of niacin will could cause pellagra. The archetypal evidence is symmetric dermatitis, diarrhea and dementia ( three D affection ). There are weight loss, weakness, aperture and argot afire sensation, indigestion, belly pain, diarrhea, headache, insomnia, forgetfulness, causticity and added aboriginal onset.

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