Fidaxomicin has been compared alone with articulate vancomycin in analytic trials for antecedent occurrences of C. difficile–associated diarrhea. In two studies enrolling a absolute of 1,057 participants, fidaxomicin (200 mg alert circadian for 10 days) was as able as vancomycin (125 mg every six hours for 10 days) at bearing analytic cure, which was authentic as the resolution of diarrhea (fewer than three baggy stools for two after days).
Fidaxomicin decreases ceremony of C. difficile infection compared with vancomycin (number bare to amusement [NNT] = 7 to 10), although it is no added able in patients who are adulterated with a hypervirulent ache of C. difficile that is added acceptable to could cause complications and recurrence. Similarly, both are appropriately able in alleviative a aboriginal recurrence, with fidaxomicin conceivably getting hardly added able in preventing a additional ceremony (NNT = 3 to 333).
Fidaxomicin has not been compared with metronidazole, and has not been advised in patients in whom analysis with metronidazole failed. All patients who accept been advised accept had accepted cases of C. difficile infection; it has not been advised in patients with added causes of antibiotic-associated diarrhea.