Dehydroepiandrosterone is a forerunner hormone which agency it has little biological aftereffect on its own, but has able furnishings if adapted into added hormones such as testosterone and oestradiol. Dehydroepiandrosterone is produced from cholesterol mainly by the alien band of the adrenal glands, accepted as the adrenal cortex, although it is aswell fabricated by the testes and ovaries in baby amounts. It circulates in the blood, mainly absorbed to sulphur as dehydroepiandrosterone sulfate which prevents the hormone getting torn down. In women, dehydroepiandrosterone is an important antecedent of oestrogens in the body: it provides about 75% of oestrogens afore the menopause, and 100% of oestrogens in the physique afterwards menopause.
Dehydroepiandrosterone assembly increases from about nine or ten years of age, peaks during the 20s and gradually decreases into old age. Dehydroepiandrosterone is aswell produced in baby amounts by the brain, although its absolute role there is not clear.