It does a lot of stuff, neurotransmitter-wise. It binds and activates mu-opioid receptors (the aforementioned receptors afflicted by painkillers). It was anticipation to bright serotonin from the synapse (“selective-serotonin re-uptake enhancement”). This appearance has mostly been rescinded. If Tianeptine does advance serotonin approval at all, this aftereffect is anemic and doesn’t accord to Tianeptine’s ability as an antidepressant.
Tianeptine aswell alters glutamate receptors in the brain. (Specifically, it modifies the phosphorylation accompaniment of these receptors, affecting arresting transduction). Tianeptine possibly promotes mesolimbic dopamine absolution and potentiates dopamine receptors.
There’s dispersed affirmation to abutment this, but my appearance is that Tianeptine reproduces the benign furnishings of exercise on cognition. To oversimplify, the “runner’s high” is apparently acquired by the absolution of accustomed opioids, like endorphins (affectionately declared as “endogenous morphine”). Since Tianeptine is a abounding agonist at the mu-opioid receptor, Tianeptine affectionate of behaves like an endorphin.