Mitiglinide is a biologic for the analysis of blazon 2 diabetes .Mitiglinide is anticipation to activate insulin beard by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells.
Mitiglinide belongs to the meglitinide chic of claret glucose-lowering drugs. It is accustomed for use in Japan but has not yet acquired FDA approval.
Mitiglinide is anticipation to activate insulin beard by bounden to and blocking ATP-sensitive K(+) (K(ATP)) channels (Kir6.2/SUR1 complex, KATP channels) in pancreatic beta-cells. Closure of potassium channels causes depolarization which stimulates calcium arrival through voltage-gated calcium channels. High intracellular calcium after triggers the exocytosis of insulin granules.