Trifluoromethyl is a anatomic accumulation in organofluorines that has the blueprint -CF3. The allotment of is accumulation is acquired from the methyl accumulation (which has the blueprint -CH3), by replacing anniversary hydrogen atom by a fluorine atom. The trifluomethyl accumulation has a cogent electronegativity that is generally declared as getting average amid the electronegativities of fluorine and chlorine.For this reason, trifluoromethyl-substituted compounds are generally able acids, such as trifluoromethanesulfonic acerbic and trifluoroacetic acid. In added cases, the trifluoromethyl accumulation is active to lower the basicity of amoebic compounds or to advise characteristic solvation backdrop (e.g. trifluoroethanol).
The trifluoromethyl accumulation occurs in assertive pharmaceuticals, drugs, and abiotically actinic accustomed fluorocarbon based compounds. The alleviative use of the trifloromethyl accumulation dates from 1928, although analysis became added acute in the mid-1940s. The trifluoromethyl accumulation is generally acclimated as a bioisostere to actualize derivatives by replacing a chloride or a methyl group. This can be acclimated to acclimatize the steric and cyberbanking backdrop of a advance compound, or to assure a acknowledging methyl accumulation from metabolic oxidation. Some notable drugs absolute trifluoromethyl groups cover efavirenz (Sustiva), an HIV about-face transcriptase inhibitor; fluoxetine (Prozac), an antidepressant; and celecoxib (Celebrex), a non-steroidal anti-inflammatory.