Auriculin B is mainly composed of atrial beef cells, academician natriuretic peptide buried chiefly by ventricular myocytes, C blazon natriuretic peptide mainly buried by vascular endothelial beef and play a vasodilatory and antiproliferative furnishings in the local. The role of a array of atrial natriuretic peptide in claret vasodilator, diuretic, neuroendocrine hormone antagonist. Auriculin B by the atrial beef corpuscle amalgam and absolution of a polypeptide. Accomplish vasodilation, decreased borderline resistance; so that anniversary achievement change is little, apathetic affection rate; renal elimination of sodium and baptize resulted in increased; extracellular aqueous aggregate reduction. It is a accumulation of altered atomic weight peptide mixture, from rat and animal affection has been abandoned from 10 breed of atriopeptin-like substance, its basal anatomy is similar, but N and C terminal amino acerbic differences or alone alone amino acid. The heart, such as sodium accepted as beta gamma three atomic forms ( see [ ] several atomic forms of atrial natriuretic peptide ), its atomic weight was about 3000, 6000 and 13000. – atrial natriuretic peptide is a basal anatomy of atrial natriuretic peptide, consisting of 28 amino acids, two two intramolecular disulfide bond, basic a ring structure. β – animal atrial natriuretic peptide composed of two mutually astern – animal atrial natriuretic peptide, a two by two disulfide bonds in parallel, can be broken into – animal atrial natriuretic peptide. γ – atrial natriuretic peptide composed of 126 amino acids, is – animal atrial natriuretic peptide precursor. Rat atrial natriuretic peptide forerunner is composed of 152 amino acids, animal atrial natriuretic peptide forerunner is composed of 151 amino acids. – 4 times of animal atrial natriuretic peptide activity is beta -, gamma – 5 times.
Auriculin B has the role of natriuretic, diuretic and strong, and has the characteristics of fast, short, strong. Injection of atrial natriuretic peptide afterwards 1 ~ 2 account of onset, continuance 30 minutes, diuretic furosemide adeptness is about 500 ~ 1000 times, but aswell access the potassium, calcium, magnesium, chloride and phosphate excretion. Atrial natriuretic agency by accretion claret breeze and arrest glomerular filtration rate, added renal medullary adjacent bizarre tubule and accession aqueduct reabsorption of sodium, the diuretic and natriuretic effect. Can arrest renal juxtaglomerular beef absolution renin, and through the inhibition of the renin angiotensin arrangement and absolute aftereffect on adrenal cortex, inhibition of aldosterone secretion, it not alone abolish aldosterone beard rate, but aswell inhibited by ACTH, angiotensin, aldosterone beard angry by potassium etc.. Atrial natriuretic peptide inhibits the activity of aldosterone may be accompanying to calcium and phospholipase A. Vasoconstriction can alienate the noradrenaline, angiotensin 5-, serotonin, histamine and potassium ions acquired by. Integrity of the aftereffect of vasodilators does not depend on endothelial cells. Atrial natriuretic peptide vasodilation aftereffect is selective, can accomplish the diastolic pulmonary, bronchial and uterine artery, the arch furnishings on aorta, carotid artery, followed by mesenteric avenue and aperture vein, jugular aftereffect of the baby claret vessels, beneath access on. The breeze of the vasodilation aftereffect and calcium ions, at the aforementioned time by reflex and dopamine arrangement acquired by blurred claret burden effect.
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