Eledoisin acetate is an undecapeptide of mollusk origin, acceptance to the tachykinin ancestors of neuropeptides.It was aboriginal abandoned from the after salivary glands of two mollusk breed Eledone muschata and Eledone aldovandi, which accord to the octopod adjustment of Cephalopoda.Other tachykinins from nonmammalian sources cover kassinin and physalaemin. The beastly tachykinins actuality P, NKA, and NKB accept agnate furnishings as tachykinins of nonmammals and accept been added broadly advised and characterized. These peptides display a advanced and circuitous spectrum of pharmacological and physiological activities such as vasodilation, hypertension, and dispatch of extravascular bland muscle.
Eledoisin acetate has the amino acerbic arrangement pGlu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH. Like all tachykinin peptides, Eledoisin shares the aforementioned accord C-terminal sequence, that is, Phe-Xxx-Gly-Leu-Met-NH. The invariant “Phe7” balance is apparently appropriate for receptor binding. “Xxx” is either an ambrosial (phenylalanine, tyrosine) or a angled aliphatic (valine, isoleucine) ancillary alternation and is anticipation to be important in receptor selectivity. This accepted region, generally referred to as the “message domain,” is believed to be amenable for activating the receptor. The aberrant N-terminal arena or the “address domain” varies in amino-acid arrangement and breadth and is believed to play a role in free the receptor subtype specificity.